Improvement in blood fluidity by Kaempferia parviflora rhizome

Kazuya Murata, Takahiro Deguchi, Takanori Fujita & Hideaki Matsuda

Abstract

Improvement in blood fluidity leads to the prevention of various lifestyle-related diseases. A raw material for improving blood fluidity has been long desired in the research area of functional and supplemental foods. We successfully showed an improvement in blood fluidity by the Zingiberaceae plant, Kaempferia parviflora. The rhizome of the plant reduced the blood passage time through a micro slit using a disseminated intravascular coagulation model. The mechanism was attributed to the activation of fibrinolysis, as demonstrated by elongation of the euglobulin lysis time and an in-vitro fibrinolysis assay. The active principles were determined to be methoxyflavones. The results show that the rhizome of K. parviflora is a promising candidate preventive agent for treating lifestyle-related diseases.


References:

Ahmed, F.R.S.; Amin, R.; Hasan, I.; Asaduzzaman, A.K.M.; Kabir, S.R. (2017), Antitumor properties of a methyl-ß-d-galactopyranoside specific lectin from Kaempferia rotunda against Ehrlich ascites carcinoma cells, International Journal of Biological Macromolecules, Vol 102, Pages 952-959

Asamenew, G.; Kim, H.-W.; Lee, M.-K.; Lee, S.-H.; Kim, Y.-J.; Cha,Y.-S.; Lim, J.-B. (2019) Characterization of phenolic compounds from normal ginger (Zingiber officinale Rosc.) and black ginger (Kaempferia parviflora Wall.) using UPLC–DAD–QToF–MS, European Food Research and Technology, Vol 245, Pages 653-665

Banjerdpongchai R, Suwannachot K, Rattanapanone V, Sripanidkulchai B. (2008), Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker induces apoptosis in HL-60 cells, Asian Pacific Journal of Cancer Prevention, Volume 9, Pages 595–600

Chaipech, S.; Morikawa, T.; Ninomiya, K.; Yoshikawa, M.l; Pongpiriyadacha, Y.; Hayakawa, T.; Muraoka, O. (2012), Structures of two new phenolic glycosides, kaempferiaosides A and B, and hepatoprotective constituents from the rhizomes of Kaempferia parviflora, Chemical and Pharmaceutical Bulletin, Vol 60, Pages 62-69

Chaturapanich, G.; Chaiyakul, S.; Verawatnapakul, V.; Yimlamai, T.; Pholpramool, C.; Enhancement of aphrodisiac activity in male rats by ethanol extract of Kaempferia parviflora and exercise training, Andrologia, Vol 44 (Suppl 1), Pages 323-328

Deema P. (2007), Effect of Kaempferia parviflora and Endurance Training on Lactate Threshold in Humans Phitsanulok, Thailand: Naresuan University

Diastuti, Hartiwi; Chasani, Mochammad; Suwandri, Suwandri (2020), Antibacterial Activity of Benzyl Benzoate and Crotepoxide from Kaempferia rotunda L. Rhizome, Indonesian Journal of Chemistry, Vol 20, No 1

Hashiguchi, Akiko; Thawtar, May San; Duangsodsri, Teerarat; Kusano, Miyako; Watanabe, Kazuo N. (2022), Biofunctional properties and plant physiology of Kaempferia spp.: Status and trends, Journal of Functional Foods Volume 92

Kobayashi, Shoko; Kato, Taro; Azuma, Toshiaki; Kikuzaki, Hiroe; Abe, Keiko (2015), Anti-allergenic activity of polymethoxyflavones from Kaempferia parviflora, Journal of Functional Foods, Volume 13, Pages 100-107

Okabe Y, Shimada T, Horikawa T, et al. (2014), Suppression of adipocyte hypertrophy by polymethoxyflavonoids isolated from Kaempferia parviflora, Phytomedicine, Volume 21 Pages 800–806

Rujjanawate, C.; Kanjanapothi, D.; Amornlerdpison, D.; Pojanagaroon, S. (2005), Anti-gastric ulcer effect of Kaempferia parviflora Journal of Ethnopharmacology, Volume 102, Pages 120-122, 10.1016/j.jep.2005.03.035

Shimada, T.; Horikawa, T. ; Ikeya, Y.; Matsuo, H.; Kinoshita, K.; Taguchi, T.; Ichinose, K.; Takahashi, K.; Aburada, M. (2011), Preventive effect of Kaempferia parviflora ethyl acetate extract and its major components polymethoxyflavonoid on metabolic diseases , Fitoterapia, Volume 82, Pages 1272-1278, 10.1016/j.fitote.2011.08.018


Available on Amazon in (please click):

https://www.amazon.com/dp/B0B5N46JPH - Black Ginger, 155 Vegetarian Capsules of 500 mg of Fermented Thai 1:60 Extract
Product details

https://www.amazon.com/dp/B0B5N6H6WK - Black Ginger, 110 Vegetarian Capsules of 500 mg of Fermented Thai 1:60 Extract
Product details

https://www.amazon.com/dp/B09T77KXBN - Black Ginger for Men - Kaempferia Parviflora Thai Grade AA 1:60 Extract, 500 mg x 30
Product details

https://www.amazon.com/dp/B09T5LYNZ9 - Black Ginger Kaempferia Parviflora (Krachai Dum, Krachai Dam, Kaempferia Parviflora) Thai Grade AA 1:60 Extract, 30 x 500 mg
Product details

https://www.amazon.com/dp/B09SSXCFDC - Kaempferia Parviflora (Krachai Dum, Krachai Dam, Black Ginger) 30 x 500 mg, Thai Grade AA 1:60 Extract
Product details

https://www.amazon.com/dp/B09SSXCFDC - Kaempferia Parviflora (Krachai Dum, Krachai Dam, Black Ginger) 30 x 500 mg, Thai Grade AA 1:60 Extract
Product details

https://www.amazon.com/dp/B09RJQYHXN - Black Ginger (Kaempferia Parviflora), 155 x 500 mg Fermented Micronized Thai Grade AA 1:60 Extract
Product details

https://www.amazon.com/dp/B09R4PKKY2 - Black Ginger 60 caps @ 600 mg (Kaempferia Parviflora), Thai Grade A 1:60 Extract
Product details

https://www.amazon.ca/dp/B09TVH4KHN - Late Harvest 30x500mg Black Ginger from Thailand 1:60 Extract in Canada
Product details

https://www.amazon.com/dp/B085GCTZY2 - Black Ginger (Kaempferia Parviflora) Grade A Extract 1:60, 80 Capsules 600 mg
Product details

https://www.amazon.com/dp/B09QJNZ7GF - Black Ginger, 95 caps @ 600 mg Thai Grade A 1:60 Extract
Product details

https://www.amazon.com/dp/B082VZWDS2 - Black Ginger (Kaempferia Parviflora) Extract 1:60, 100 Capsules 600 mg
Product details

https://www.amazon.com/dp/B082VZR8WD - Black Ginger (Kaempferia Parviflora) Extract 1:60, 100 Capsules 600 mg
Product details

https://www.amazon.com/dp/B09QJSZFZT - Black Ginger (Kaempferia Parviflora) Extract 1:60, 115 Capsules 600 mg
Product details